Cyclobenzaprine Flexeril Side Effects, Interactions, Uses, Dosage, Warnings

This can result in slowed and reduced breathing, extreme sedation, and, in some cases, coma or even death. If you are taking another medication that also causes drowsiness, you may have more side effects. Your care team will tell you how much medication to take. Call emergency for help if you have problems breathing or unusual sleepiness. If this medication upsets your stomach, take it with food or milk.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). View interaction reports for Flexeril (cyclobenzaprine) and the medicines listed below. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL cymbalta with flexeril 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).

Drowsiness, dizziness, dry mouth, constipation, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Using drinks containing alcohol can increase your risk of dizziness, drowsiness, and decreased alertness from cyclobenzaprine.

Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient.

Potential Risks

Do not take this drug again if you’ve ever had an allergic reaction to it. When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it. One must exercise caution and ideally ask for a doctor’s advice when combining and taking other drugs with Flexeril. Remember that the majority of the drugs that are known to interact with Cyclobenzaprine pose moderate to severe risks and side effects.

If any of these effects last or get worse, tell your doctor or pharmacist promptly. Cyclobenzaprine caused slight to moderate increase in heart rate in animals. Buspirone is an anti-anxiety prescription medication that may have a moderate drug-drug interaction when mixed with cannabis. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

Cyclobenzaprine: Side Effects, dosage, uses, and more – Medical News Today

Cyclobenzaprine: Side Effects, dosage, uses, and more.

Posted: Fri, 22 May 2020 13:31:24 GMT [source]

It is advised not to use the two together as it can increase the risk of side effects such as confusion, trouble concentrating, dizziness, and drowsiness. Some individuals, especially the elderly, may also experience impaired judgment, thinking, and poor motor coordination. It is highly recommended not to use weed while on Flexeril, especially when doing anything requiring focus and mental alertness, such as driving motor vehicles or operating heavy machinery. Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications.

Drugs you should not take with cyclobenzaprine

FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. This is a summary and does NOT have all possible information about this product.

• Check with your doctor before taking any of the above while you are using this medicine.
• Do not use in larger or smaller amounts or for longer than recommended.
• HealthLinkBC Files are easy-to-understand fact sheets on a range of public health and safety topics including disease prevention and immunizations.

Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease.

Cyclobenzaprine And Alcohol

The kidneys of older adults may not work as well as they used to. As a result, more of a drug stays in your body for longer. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.